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Protein Coding Gene : Pak2 p21 (RAC1) activated kinase 2
Primary Identifier  MGI:1339984 Organism  mouse, laboratory
Chromosome  16 NCBI Gene Number  224105
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables protein serine/threonine kinase activity. Acts upstream of or within cellular response to organic cyclic compound and dendritic spine development. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including brain and corpus striatum. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in ductal carcinoma in situ. Orthologous to human PAK2 (p21 (RAC1) activated kinase 2).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit lethality between E8 and the postnatal period with prominent head folds, impaired somite development, and growth retardation. Mice homozygous for a knock-in allele exhibit increased cell proliferation and decreased apoptosis. [provided by MGI curators]
  • synonyms:
  • D16Ertd269e,
  • Pak2,
  • DNA segment, Chr 16, ERATO Doi 269, expressed,
  • MGI:2146488,
  • expressed sequence AI836325,
  • PAK-2,
  • RIKEN cDNA A130002K10 gene,
  • MGI:2442429,
  • A130002K10Rik,
  • AI836325,
  • MGI:1098647,
  • 5330420P17Rik,
  • MGI:1924351,
  • p21 (RAC1) activated kinase 2,
  • RIKEN cDNA 5330420P17 gene
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