| First Author | Kirsch IR | Year | 1997 |
| Journal | Semin Immunol | Volume | 9 |
| Issue | 3 | Pages | 207-15 |
| PubMed ID | 9200332 | Mgi Jnum | J:42638 |
| Mgi Id | MGI:1096069 | Doi | 10.1006/smim.1997.0071 |
| Citation | Kirsch IR, et al. (1997) Lymphocyte-specific genomic instability and risk of lymphoid malignancy. Semin Immunol 9(3):207-15 |
| abstractText | Genetic instability is a force that links evolution, development and cancer. We have developed a quantifiable assay for a particular kind of lymphocyte-specific genetic instability (antigen receptor trans-rearrangements) mediated by the V(D)J recombinase complex. We find that the level of this type of instability correlates (at the population level) with risk for lymphoid malignancy. We have developed a murine model for this measure of instability to allow a more refined analysis of the genetic and environmental factors that sum to define population cancer risk. |
