| First Author | Wan CK | Year | 2016 |
| Journal | J Immunol | Volume | 196 |
| Issue | 2 | Pages | 543-6 |
| PubMed ID | 26643477 | Mgi Jnum | J:253726 |
| Mgi Id | MGI:6102426 | Doi | 10.4049/jimmunol.1502080 |
| Citation | Wan CK, et al. (2016) Cutting Edge: IL-1 Receptor Signaling is Critical for the Development of Autoimmune Uveitis. J Immunol 196(2):543-6 |
| abstractText | IL-1beta is a proinflammatory cytokine important for local and systemic immunity. However, aberrant production of this cytokine is implicated in pathogenic mechanisms of a number of inflammatory diseases, including Behcet''s disease and age-related macular degeneration. In this study, we report the increased secretion of IL-1beta in the retina by neutrophils, macrophages, and dendritic cells during ocular inflammation and show that loss of IL-1R signaling confers protection from experimental autoimmune uveitis. Moreover, the amelioration of experimental autoimmune uveitis in Il1r-deficient mice was associated with reduced infiltration of inflammatory cells into the retina and decreased numbers of uveitogenic Th17 cells that mediate uveitis. These findings indicate the possible utility of IL-1R-blocking agents for the treatment of ocular inflammatory diseases. |
