| First Author | Pardi MB | Year | 2020 |
| Journal | Science | Volume | 370 |
| Issue | 6518 | Pages | 844-848 |
| PubMed ID | 33184213 | Mgi Jnum | J:299199 |
| Mgi Id | MGI:6479660 | Doi | 10.1126/science.abc2399 |
| Citation | Pardi MB, et al. (2020) A thalamocortical top-down circuit for associative memory. Science 370(6518):844-848 |
| abstractText | The sensory neocortex is a critical substrate for memory. Despite its strong connection with the thalamus, the role of direct thalamocortical communication in memory remains elusive. We performed chronic in vivo two-photon calcium imaging of thalamic synapses in mouse auditory cortex layer 1, a major locus of cortical associations. Combined with optogenetics, viral tracing, whole-cell recording, and computational modeling, we find that the higher-order thalamus is required for associative learning and transmits memory-related information that closely correlates with acquired behavioral relevance. In turn, these signals are tightly and dynamically controlled by local presynaptic inhibition. Our results not only identify the higher-order thalamus as a highly plastic source of cortical top-down information but also reveal a level of computational flexibility in layer 1 that goes far beyond hard-wired connectivity. |
