| Primary Identifier | MGI:88054 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 11813 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable several functions, including identical protein binding activity; lipase activator activity; and phospholipase binding activity. Predicted to be involved in several processes, including lipid transport; negative regulation of transport; and regulation of lipid metabolic process. Predicted to be located in extracellular space. Predicted to be part of several cellular components, including low-density lipoprotein particle; spherical high-density lipoprotein particle; and triglyceride-rich plasma lipoprotein particle. Is expressed in several structures, including capillary; central nervous system; liver; lung; and yolk sac endoderm. Human ortholog(s) of this gene implicated in familial apolipoprotein C-II deficiency; familial hyperlipidemia; and multiple sclerosis. Orthologous to human APOC2 (apolipoprotein C2). PHENOTYPE: Mice homozygous for an endonuclease-mediated allele exhibit increased circulating triglyceride, decreased circulating HDL cholesterol, and abnormal lipoprotein levels. Mice heterozygous for the allele exhibit an intermediate phenotype. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
