| First Author | Sretavan DW | Year | 1994 |
| Journal | Neuron | Volume | 12 |
| Issue | 5 | Pages | 957-75 |
| PubMed ID | 7514428 | Mgi Jnum | J:18156 |
| Mgi Id | MGI:66171 | Doi | 10.1016/0896-6273(94)90307-7 |
| Citation | Sretavan DW, et al. (1994) Embryonic neurons of the developing optic chiasm express L1 and CD44, cell surface molecules with opposing effects on retinal axon growth. Neuron 12(5):957-75 |
| abstractText | The first retinal ganglion cell axons arriving at the embryonic mouse ventral diencephalon encounter an inverted V-shaped neuronal array defining the midline and posterior boundaries of the future optic chiasm. These neurons express L1, an immunoglobulin superfamily molecule known to promote retinal axon outgrowth, and CD44, a cell surface molecule that we find inhibits embryonic retinal axon growth in vitro. Incoming retinal axons do not penetrate this L1/CD44 neuron array, but turn to establish the characteristic X-shaped optic chiasm along the anterior border of this array. These results suggest that L1/CD44 neurons may serve as an anatomical template for retinal axon pathways at the embryonic mouse ventral diencephalon. |
