| First Author | Kotlyarov A | Year | 1999 |
| Journal | Nat Cell Biol | Volume | 1 |
| Issue | 2 | Pages | 94-7 |
| PubMed ID | 10559880 | Mgi Jnum | J:59678 |
| Mgi Id | MGI:1352048 | Doi | 10.1038/10061 |
| Citation | Kotlyarov A, et al. (1999) MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis [see comments]. Nat Cell Biol 1(2):94-7 |
| abstractText | MAPKAP kinase 2 (MK2) is one of several kinases that are regulated through direct phosphorylation by p38 MAP kinase. By introducing a targeted mutation into the mouse MK2 gene, we have determined the physiological function of MK2 in vivo. Mice that lack MK2 show increased stress resistance and survive LPS-induced endotoxic shock. This is due to a reduction of approximately 90% in the production of tumor necrosis factor-alpha (TNF-alpha) and not to a change in signalling from the TNF receptor. The level and stability of TNF-alpha mRNA is not reduced and TNF-alpha secretion is not affected. We conclude that MK2 is an essential component in the inflammatory response which regulates biosynthesis of TNF-alpha at a post-transcriptional level. |
