| First Author | Nomoto M | Year | 2016 |
| Journal | Nat Commun | Volume | 7 |
| Pages | 12319 | PubMed ID | 27477539 |
| Mgi Jnum | J:241159 | Mgi Id | MGI:5897933 |
| Doi | 10.1038/ncomms12319 | Citation | Nomoto M, et al. (2016) Cellular tagging as a neural network mechanism for behavioural tagging. Nat Commun 7:12319 |
| abstractText | Behavioural tagging is the transformation of a short-term memory, induced by a weak experience, into a long-term memory (LTM) due to the temporal association with a novel experience. The mechanism by which neuronal ensembles, each carrying a memory engram of one of the experiences, interact to achieve behavioural tagging is unknown. Here we show that retrieval of a LTM formed by behavioural tagging of a weak experience depends on the degree of overlap with the neuronal ensemble corresponding to a novel experience. The numbers of neurons activated by weak training in a novel object recognition (NOR) task and by a novel context exploration (NCE) task, denoted as overlapping neurons, increases in the hippocampal CA1 when behavioural tagging is successfully achieved. Optical silencing of an NCE-related ensemble suppresses NOR-LTM retrieval. Thus, a population of cells recruited by NOR is tagged and then preferentially incorporated into the memory trace for NCE to achieve behavioural tagging. |
