| Primary Identifier | MGI:98847 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 104263 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables chromatin binding activity; histone H3K9 demethylase activity; and transcription coregulator activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of transcription by RNA polymerase II; and spermatid nucleus elongation. Located in cytoplasm and male germ cell nucleus. Is expressed in several structures, including cerebral cortex; extraembryonic ectoderm; and pituitary gland. Used to study obesity. Human ortholog(s) of this gene implicated in cervical cancer and colon cancer. Orthologous to human KDM3A (lysine demethylase 3A). PHENOTYPE: Male mice homozygous for a hypomorphic allele display infertility, oligoasthenoteratozoospermia, small testis, and impaired spermiogenesis. Mice homozygous for a null allele exhibit abnormal spermatogenesis and obesity associated with hyperlipidemia. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
