Primary Identifier | MGI:107685 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 18844 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables semaphorin receptor activity. Involved in gonadotrophin-releasing hormone neuronal migration to the hypothalamus and olfactory nerve formation. Acts upstream of or within several processes, including dichotomous subdivision of terminal units involved in salivary gland branching; neuron projection morphogenesis; and semaphorin-plexin signaling pathway. Located in membrane. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; cranial nerve; genitourinary system; lung; and sensory organ. Orthologous to human PLXNA1 (plexin A1). PHENOTYPE: Mice homozygous for a null allele exhibit bone cellularity abnormalities, altered dendritic cell physiology, abnormal proprioceptive and oligodendrocyte morphology, and increased lymphatic branching complexity and LEC numbers. [provided by MGI curators] |