Primary Identifier | MGI:105931 | Organism | mouse, laboratory |
Chromosome | 3 | NCBI Gene Number | 20957 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable double-stranded DNA binding activity. Involved in reciprocal meiotic recombination and synaptonemal complex assembly. Acts upstream of or within meiosis I cell cycle process; regulation of protein localization; and sperm DNA condensation. Located in autosome; male germ cell nucleus; and synaptonemal complex. Is expressed in several structures, including brain; heart; and reproductive system. Orthologous to human SYCP1 (synaptonemal complex protein 1). PHENOTYPE: Homozygous null mice display male and female infertility, azoospermia, small ovary, small testis and seminiferous tubules, absent ovarian follicles, and failure of synapse formation during meiosis. [provided by MGI curators] |