Primary Identifier | MGI:109234 | Organism | mouse, laboratory |
Chromosome | 1 | NCBI Gene Number | 16565 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Acts upstream of or within corpus callosum development. Predicted to be located in cell projection; cytoplasmic vesicle; and cytoskeleton. Predicted to be part of kinesin complex. Predicted to be active in microtubule. Is expressed in central nervous system; dorsal root ganglion; and neural retina. Orthologous to human KIF21B (kinesin family member 21B). PHENOTYPE: Homozygous KO reduces dendrite branching and spine density as a result of reduced microtubule growth, resulting in impaired spatial learning and cued conditioning behavior. [provided by MGI curators] |