| Primary Identifier | MGI:103309 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 14252 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable ionotropic glutamate receptor binding activity and protease binding activity. Involved in anterograde dendritic transport; regulation of myoblast differentiation; and regulation of postsynaptic membrane neurotransmitter receptor levels. Located in acrosomal membrane and caveola. Part of flotillin complex. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human FLOT2 (flotillin 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced metastasis into the lungs in a breast cancer model. Homozygous double KO with Flot1 increases susceptibility to induced necroptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
