| Primary Identifier | MGI:1100500 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 14251 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable ionotropic glutamate receptor binding activity and protease binding activity. Involved in several processes, including positive regulation of cell-cell adhesion mediated by cadherin; positive regulation of cellular component organization; and positive regulation of dopaminergic synaptic transmission. Acts upstream of or within axonogenesis and regulation of Rho protein signal transduction. Located in caveola; external side of plasma membrane; and sarcolemma. Part of flotillin complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human FLOT1 (flotillin 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired neutrophil recruitment. Homozygous double KO with Flot2 increases susceptibility to induced necroptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
