| First Author | Yang W | Year | 2012 |
| Journal | Mol Cell Neurosci | Volume | 49 |
| Issue | 4 | Pages | 406-14 |
| PubMed ID | 22365952 | Mgi Jnum | J:196731 |
| Mgi Id | MGI:5489827 | Doi | 10.1016/j.mcn.2012.02.002 |
| Citation | Yang W, et al. (2012) Aquaporin-4 mediates astrocyte response to beta-amyloid. Mol Cell Neurosci 49(4):406-14 |
| abstractText | It has been demonstrated that the water channel protein aquaporin-4 (AQP4) plays an important role in astrocyte plasticity in response to a variety of injuries or stimuli. However, the potential role of AQP4 in astrocyte response to beta-amyloid (Abeta) has not been studied. The purpose of this study was to investigate this issue. Compared to media control, the lower concentrations of Abeta(1-42) (0.1-1 muM) increased AQP4 expression in cultured mouse cortical astrocytes, while the higher concentrations of Abeta(1-42) (10 muM) decreased AQP4 expression. AQP4 gene knockout reduced Abeta(1-42)-induced astrocyte activation and apoptosis, which was associated with a reduction in the uptake of Abeta via decreased upregulation of low-density lipoprotein receptor related protein-1. Moreover, time-course and levels of Abeta(1-42)-induced mitogen-activated protein kinase phosphorylation were altered in AQP4 null astrocytes compared with wild-type controls. Our data reveal a novel role of AQP4 in the uptake of Abeta by astrocytes, indicating that AQP4 is a molecular target for Alzheimer's disease. |
