| Type | MGI:General | Description | at E9.5, ~66.6% of homozygotes display abnormal yolk sac vessels with strands of acellular material connecting endoderm and mesothelium vascular yolk-sac defects precede embryo wasting and necrosis and are noted in embryos still embedded in their decidua at E9.5, fragility of mutant vitelline vessels is associated with lack of mesenchymal cell/pericyte accumulation and function, reduced extracellular matrix, and hypoplasia of the muscular wall of primitive vessels; in contrast, endoderm, endothelial and mesothelial cells appear normal |
