| Primary Identifier | IPR039896 | Type | Family |
| Short Name | Red-like |
| description | Protein RED (also known as IK) is found in the nucleus and is a component of the spliceosome []. It is also associated with the spindle pole where it co-localizes with and interacts with the spindle assembly checkpoint protein MAD1 during metaphase and anaphase. Depletion of RED shortens the mitotic cycle and MAD1 is incorrectly localized [].Proteins in this entry also include SPBC1539.02 from the fission yeast and smu-2 from C. elegans. SPBC1539.02 is required for chromosome segregation during meiosis []. SMU-2 and SMU-1 bind to each other as components of the spliceosome and modulate splice site selection of many pre-mRNAs [].Protein RED and related proteins contain an arginine/glutamic acid/aspartic acid repetitive sequence. The region in question has several conserved NLS sequences and a putative trimeric coiled-coil region, indicative that these proteins are expressed in the nucleus []. |
