Primary Identifier | MGI:5606181 | Allele Type | Targeted |
Gene | Pten | Transmission | Germline |
Strain of Origin | (C57BL/6 x 129S4/SvJae)F1 | Is Recombinase | false |
Is Wild Type | false |
molecularNote | Nucleotide substitutions in exon 5 were introduced by homologous recombination to alter codon 129 from one encoding glycine to encoding glutamic acid (Gly129Glu). An adjacent loxP-flanked neomycin selection cassette that was inserted in to intron 5 was removed by cre-mediated recombination. |