Primary Identifier | MGI:1929711 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 56317 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable enzyme-substrate adaptor activity and protein phosphatase binding activity. Predicted to be involved in several processes, including brain development; positive regulation of mitotic metaphase/anaphase transition; and protein K11-linked ubiquitination. Predicted to be located in nucleus and spindle. Predicted to be part of anaphase-promoting complex and heterochromatin. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Used to study syndromic intellectual disability. Orthologous to human ANAPC7 (anaphase promoting complex subunit 7). PHENOTYPE: Mice homozygous for a null allele exhibit impaired swimming,difficulty moving on a pole, increased contextual freezing, and juvenile growth retardation. [provided by MGI curators] |