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Protein Coding Gene : Cdk2 cyclin dependent kinase 2

Primary Identifier  MGI:104772 Organism  mouse, laboratory
Chromosome  10 NCBI Gene Number  12566
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables cyclin binding activity; cyclin-dependent protein serine/threonine kinase activity; and magnesium ion binding activity. Involved in positive regulation of cell population proliferation. Acts upstream of or within G1/S transition of mitotic cell cycle; potassium ion transport; and regulation of nucleobase-containing compound metabolic process. Located in chromosome and nucleus. Part of cyclin-dependent protein kinase holoenzyme complex and transcription regulator complex. Is expressed in several structures, including brain; branchial arch; ear; integumental system; and limb. Human ortholog(s) of this gene implicated in prostate cancer and renal cell carcinoma. Orthologous to human CDK2 (cyclin dependent kinase 2).
PHENOTYPE: Reproductive system abnormalities are observed in mice homozygous for disruptions in this gene. Gametogenesis fails in both males and females, leading to atrophy of the testes and ovaries. Both sexes are sterile. [provided by MGI curators]
  • synonyms:
  • MGD-MRK-28064,
  • cyclin dependent kinase 2,
  • MGI:2443873,
  • RIKEN cDNA A630093N05 gene,
  • Cdk2,
  • A630093N05Rik

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

1 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

62 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For