| Primary Identifier | IPR030125 | Type | Family |
| Short Name | SPIN90/Ldb17 |
| description | This entry includes SPIN90 from animals, Ldb17 from budding yeasts and Dip1 from fission yeasts.Protein Ldb17 is recruited to cortical actin patches before actin polymerisation and regulates normal coat dynamics and actin assembly []. It is a component of the endocytic machinery [].SPIN90, also known as NCK interacting protein with SH3 domain (NCKIPSD), is an F-actin binding protein that regulates actin polymerization and endocytosis []. It associates with the Arp2/3 complex near actin filaments and determines filament localization at the leading edge of lamellipodia []. SPIN90 is expressed in the early stages of neuronal differentiation and plays a role in regulating growth cone dynamics and neurite outgrowth []. It also interacts with IRSp53 and regulates cell motility by playing a role in the formation of membrane protrusions []. SPIN90 contains an N-terminal SH3 domain, a proline-rich domain, and a C-terminal VCA (verprolin-homology and cofilin-like acidic) domain []. |
