Primary Identifier | MGI:6283859 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Del(11Krt31c)2Tmm |
Transmission | Germline | Strain of Origin | 129S7/SvEvBrd |
Is Recombinase | false | Is Wild Type | false |
molecularNote | LoxP sites were inserted 5' and 3' of the keratin type I gene cluster. Cre mediated recombination deleted the entire cluster leaving a single loxP site from Krt222 to Krt17. The absence of the transcripts and gene products was confirmed by RT-PCR and immunofluorescence microscopy in homozygous embryos. ES cells carrying Krt31ctm1Tmm and Krt31ctm2Tmm and were used to create this deletion. |