Primary Identifier | MGI:4880744 | Allele Type | Targeted |
Attribute String | Modified regulatory region, Null/knockout, Reporter | Gene | Igf2 |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Alternative exon 1, including the second alternative promoter P2 upstream of it (Rr145), was replaced with a lacZ-neo cassette via homologous recombination. Real-time PCR analysis showed reduced total transcripts throughout development. However, no reduction in total protein level was detected during development. |