| Primary Identifier | IPR035260 | Type | Family |
| Short Name | Fin1 |
| description | Fin1 forms filaments between the spindle pole bodies of dividing cells []and localizes to spindle microtubules during anaphase. It contributes to spindle stability. The C-terminal half of Fin1 contains coiled-coil motifs that are required for its self-association. The N-terminal half of Fin1 can be phosphorylated at multiple sites by the cyclin-dependent kinase Clb5-Cdk1, and dephosphorylation in anaphase triggers its localization to the spindle []. Fin1 form a complex with phosphatase PP1, this complex is then recruited onto kinetochores promoting spindle assembly checkpoint (SAC) dis-assembly during anaphase [, ]. Fin1 has two RXXS/T sequences: S377 (RVTS), S526 (RKVS) that can be phosphorylated. Upon phosphorylation, interactions with other proteins such as Bmh1 and Bmh2 is promoted. However, de-phosphorylation during anaphase promotes the kinetochore recruitment of Fin1-PP1 []. |
