| First Author | Chen H | Year | 2014 |
| Journal | FEBS Lett | Volume | 588 |
| Issue | 3 | Pages | 429-35 |
| PubMed ID | 24333578 | Mgi Jnum | J:206299 |
| Mgi Id | MGI:5550001 | Doi | 10.1016/j.febslet.2013.12.002 |
| Citation | Chen H, et al. (2014) MicroRNA-344 inhibits 3T3-L1 cell differentiation via targeting GSK3beta of Wnt/beta-catenin signaling pathway. FEBS Lett 588(3):429-35 |
| abstractText | Differentiation of 3T3-L1 cells into adipocytes involves a highly orchestrated series of complex events in which microRNAs might play an essential role. In this study, we found that the overexpression of microRNA-344 (miR-344) inhibits 3T3-L1 cell differentiation and decreases triglyceride accumulation after MDI stimulation. We demonstrated that miR-344 directly targets the 3' UTR of GSK3beta (Glycogen synthase kinase 3 beta). Knockdown of GSK3beta with siRNA results in inhibiting 3T3-L1 differentiation, while its overexpression restores the effect of miR-344. In addition, miR-344 elevates the level of active beta-catenin, which is the downstream effector of GSK3beta in the Wnt/beta-catenin signaling pathway. These data indicate that miR-344 inhibits adipocyte differentiation via targeting GSK3beta and subsequently activating the Wnt/beta-catenin signaling pathway. |
