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Protein Coding Gene : Napa N-ethylmaleimide sensitive fusion protein attachment protein alpha
Primary Identifier  MGI:104563 Organism  mouse, laboratory
Chromosome  7 NCBI Gene Number  108124
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables syntaxin binding activity. Involved in regulation of synaptic vesicle priming and synaptic vesicle priming. Acts upstream of or within several processes, including SNARE complex disassembly; apical protein localization; and nervous system development. Located in myelin sheath. Part of synaptobrevin 2-SNAP-25-syntaxin-1a complex. Is active in glutamatergic synapse. Is expressed in central nervous system; peripheral nervous system ganglion; and retina. Orthologous to human NAPA (NSF attachment protein alpha).
PHENOTYPE: The homozygous null mutation is embryonic lethal while partial loss of function homozygous mutants develop hydrocephalus and die postnatally. These mutants also display central nervous system abnormalities and impaired motor capabilities. [provided by MGI curators]
  • synonyms:
  • 1500039N14Rik,
  • MGI:2142218,
  • N-ethylmaleimide sensitive fusion protein attachment protein alpha,
  • SNARE,
  • a-SNAP,
  • MGD-MRK-11037,
  • RIKEN cDNA 1500039N14 gene,
  • hyh,
  • MGI:96302,
  • RA81,
  • SNAPA,
  • Napa,
  • MGD-MRK-25997,
  • MGI:1328319,
  • AW209189,
  • MGI:1914252,
  • hydrocephaly with hop gait,
  • expressed sequence AW209189
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