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Publication : The role of PML in tumor suppression.

First Author  Salomoni P Year  2002
Journal  Cell Volume  108
Issue  2 Pages  165-70
PubMed ID  11832207 Mgi Jnum  J:76927
Mgi Id  MGI:2180610 Doi  10.1016/s0092-8674(02)00626-8
Citation  Salomoni P, et al. (2002) The role of PML in tumor suppression. Cell 108(2):165-70
abstractText  The PML gene, involved in the t(15;17) chromosomal translocation of acute promyelocytic leukemia (APL), encodes a protein which localizes to the PML-nuclear body, a subnuclear macromolecular structure. PML controls apoptosis, cell proliferation, and senescence. Here, we review the current understanding of its role in tumor suppression.
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