| First Author | Xiao B | Year | 1998 |
| Journal | Neuron | Volume | 21 |
| Issue | 4 | Pages | 707-16 |
| PubMed ID | 9808458 | Mgi Jnum | J:50718 |
| Mgi Id | MGI:1309640 | Doi | 10.1016/s0896-6273(00)80588-7 |
| Citation | Xiao B, et al. (1998) Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron 21(4):707-16 |
| abstractText | Homer is a neuronal immediate early gene (IEG) that is enriched at excitatory synapses and binds group 1 metabotropic glutamate receptors (mGluRs). Here, we characterize a family of Homer-related proteins derived from three distinct genes. Like Homer IEG (now termed Homer 1a), all new members bind group 1 mGluRs. In contrast to Homer 1a, new members are constitutively expressed and encode a C-terminal coiled- coil (CC) domain that mediates self-multimerization. CC-Homers form natural complexes that cross-link mGluRs and are enriched at the postsynaptic density. Homer 1a does not multimerize and blocks the association of mGluRs with CC-Homer complexes. These observations support a model in which the dynamic expression of Homer 1a competes with constitutively expressed CC-Homers to modify synaptic mGluR properties. |
