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Protein Coding Gene : Mcm4 minichromosome maintenance complex component 4
Primary Identifier  MGI:103199 Organism  mouse, laboratory
Chromosome  16 NCBI Gene Number  17217
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables single-stranded DNA binding activity. Contributes to DNA helicase activity. Acts upstream of or within DNA unwinding involved in DNA replication. Part of MCM complex. Is expressed in several structures, including brain; future brain; limb; metanephros; and myocardium layer. Human ortholog(s) of this gene implicated in immunodeficiency 54. Orthologous to human MCM4 (minichromosome maintenance complex component 4).
PHENOTYPE: Disruption of this allele cause chromosomal instability as assessed by micronucleus levels in erythrocytes. Mice homozygous for a spontaneous allele exhibit early onset T cell acute lymphoblastic leukemia. [provided by MGI curators]
  • synonyms:
  • AI325074,
  • MGI:2146413,
  • cell division cycle 21 (S.pombe),
  • MGI:2146584,
  • AU045576,
  • 19G,
  • MGD-MRK-24067,
  • Cdc21,
  • expressed sequence AI325074,
  • Mcmd4,
  • expressed sequence AU045576,
  • minichromosome maintenance complex component 4,
  • Mcm4,
  • mini chromosome maintenance deficient 4 homolog (S. cerevisiae),
  • mCdc21
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Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

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Disease

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