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Protein Coding Gene : Orc4 origin recognition complex, subunit 4
Primary Identifier  MGI:1347043 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  26428
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Predicted to enable DNA replication origin binding activity and nucleotide binding activity. Involved in polar body extrusion after meiotic divisions and protein polymerization. Acts upstream of or within DNA replication. Is active in cytoplasm. Is expressed in brain; embryo; and pancreas epithelium. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 2. Orthologous to human ORC4 (origin recognition complex subunit 4).
PHENOTYPE: Mice homozygous for a conditional allele activated in oocytes exhibit female infertility due to failure of polar body extrusion, impaired DNA synthesis, and arrested female meiosis. [provided by MGI curators]
  • synonyms:
  • Orc4l,
  • mMmORC4,
  • Orc4P,
  • origin recognition complex, subunit 4,
  • Orc4,
  • origin recognition complex, subunit 4-like (S. cerevisiae)
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Genome

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1 Involved In Mutations

Trail: ProteinCodingGene

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0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

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Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Function

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Homology

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Interactions

17 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

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