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Allele : Tg(GFAP-TAg121)1Tvd transgene insertion 1, Terry Van Dyke
Primary Identifier  MGI:2445447 Allele Type  Transgenic
Attribute String  Inserted expressed sequence Gene  Tg(GFAP-TAg121)1Tvd
Strain of Origin  (C57BL/6 x DBA/2)F1 Is Recombinase  false
Is Wild Type  false
molecularNote  This allele was derived from mating Tg(GFAP-lacZ-TAg121)92Tvd animals to mice carrying a cre transgene (Tg(ACTB-cre)2Mrt). As a result the intervening floxed lacZ cassette was removed, leaving a single loxP site and allowing transcription from the mutant SV40 T antigen sequence. The mutant SV40 T antigen 121 contains a deletion for the small t antigen-specific splice signal and a deletion that results in truncation of the large T antigen at amino acid 121. The mutant antigen binds RB1/RBL1/RBL2 but not TRP53. Immunohistochemical analysis of progeny showed diffuse expression of this transgene throughout the brain.
  • mutations:
  • Insertion
  • synonyms:
  • GdeltaZT121,
  • Tg(GFAP-SV40T)2.1Tvd,
  • TgG(deltaZ)T121,
  • Tg(GFAP-SV40T)2.1Tvd,
  • Tg(GFAP-T121)2.1Tvd,
  • GdeltaZT121,
  • Tg(GFAP-T121)2.1Tvd,
  • G(deltaZ)T121,
  • TgG(deltaZ)T121,
  • G(deltaZ)T121
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1 Feature

Trail: Allele

Genome

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0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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