| First Author | Peng C | Year | 2022 |
| Journal | Immunity | Volume | 55 |
| Issue | 1 | Pages | 98-114.e5 |
| PubMed ID | 34932944 | Mgi Jnum | J:321767 |
| Mgi Id | MGI:6874624 | Doi | 10.1016/j.immuni.2021.11.017 |
| Citation | Peng C, et al. (2022) Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8(+) tissue-resident memory T cells. Immunity 55(1):98-114.e5 |
| abstractText | Elevated gene expression of the costimulatory receptor Icos is a hallmark of CD8(+) tissue-resident memory (Trm) T cells. Here, we examined the contribution of ICOS in Trm cell differentiation. Upon transfer into WT mice, Icos(-/-) CD8(+) T cells exhibited defective Trm generation but produced recirculating memory populations normally. ICOS deficiency or ICOS-L blockade compromised establishment of CD8(+) Trm cells but not their maintenance. ICOS ligation during CD8(+) T cell priming did not determine Trm induction; rather, effector CD8(+) T cells showed reduced Trm differentiation after seeding into Icosl(-/-) mice. Icos(YF/YF) CD8(+) T cells were compromised in Trm generation, indicating a critical role for PI3K signaling. Modest transcriptional changes in the few Icos(-/-) Trm cells suggest that ICOS-PI3K signaling primarily enhances the efficiency of CD8(+) T cell tissue residency. Thus, local ICOS signaling promotes production of Trm cells, providing insight into the contribution of costimulatory signals in the generation of tissue-resident populations. |
