| First Author | Monsoro-Burq A | Year | 2000 |
| Journal | Mech Dev | Volume | 97 |
| Issue | 1-2 | Pages | 105-8 |
| PubMed ID | 11025211 | Mgi Jnum | J:65442 |
| Mgi Id | MGI:1926582 | Doi | 10.1016/s0925-4773(00)00417-2 |
| Citation | Monsoro-Burq A, et al. (2000) Left-right asymmetry in BMP4 signalling pathway during chick gastrulation. Mech Dev 97(1-2):105-8 |
| abstractText | Determination of the left-right (L-R) axis was shown recently to implicate several genes, among which TGFbeta-related molecules such as Activin betaB, lefty1 and 2 and Nodal. We show here that Bmp4 and its signal transduction pathway partners BMPR IA and Smad1 are transiently expressed on the right side of Hensen's node, when L-R polarity is being established. Moreover, Smad1 is expressed asymmetrically in the nascent notochord. These observations suggest a role for a BMP4-dependent autocrine or paracrine mechanism during early L-R determination. |
