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Allele : Tg(Myh6-Akt1*)6445Gcon transgene insertion 6445, Gianluigi Condorelli

Primary Identifier  MGI:6721418 Allele Type  Transgenic
Attribute String  Constitutively active, Inserted expressed sequence Gene  Tg(Myh6-Akt1*)6445Gcon
Is Recombinase  false Is Wild Type  false
molecularNote  This transgene insert contains the following elements: mouse cardiac muscle myosin heavy polypeptide 6 alpha promoter sequence to drive the heart-specific expression of a constitutively active mutated form of the mouse thymoma viral proto-oncogene 1 cDNA where codon 40 was changed from glutamic acid to lysine (p.E40K) through a G-to-A point mutation (c.118G>A), and SV40 intron and poly(A) signal sequences.
  • mutations:
  • Insertion
  • synonyms:
  • CAkt<tg>,
  • CAkt<tg>,
  • E40K-Akt,
  • E40K-Akt,
  • alphaMHC-Akt<tg>,
  • alphaMHC-Akt<tg>
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1 Feature

Trail: Allele

Genome

1 Expresses

Trail: Allele

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

Trail: Allele

0 Driven By

7 Publication categories

Trail: Allele