| Primary Identifier | MGI:97572 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 18673 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables transcription corepressor activity. Involved in several processes, including CD40 signaling pathway; modulation by host of viral RNA genome replication; and positive regulation of non-canonical NF-kappaB signal transduction. Acts upstream of or within DNA biosynthetic process and negative regulation of transcription by RNA polymerase II. Located in several cellular components, including cell surface; mitochondrial inner membrane; and nucleus. Part of mitochondrial prohibitin complex. Is expressed in cerebral cortex ventricular layer; cortical plate; ectoplacental cone; embryo; and extraembryonic ectoderm. Human ortholog(s) of this gene implicated in breast cancer and sporadic breast cancer. Orthologous to human PHB1 (prohibitin 1). PHENOTYPE: Mice homozygous for a gene trapped allele exhibit early embryonic lethality while heterozygotes exhibit altered mammary gland development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
