| First Author | Klemsz M | Year | 1994 |
| Journal | Genomics | Volume | 20 |
| Issue | 2 | Pages | 291-4 |
| PubMed ID | 8020980 | Mgi Jnum | J:17414 |
| Mgi Id | MGI:65452 | Doi | 10.1006/geno.1994.1169 |
| Citation | Klemsz M, et al. (1994) PE-1, a novel ETS oncogene family member, localizes to chromosome 1q21-q23. Genomics 20(2):291-4 |
| abstractText | The v-ets oncogene family shares a conserved peptide motif called the ETS domain that mediates sequence-specific DNA binding. This motif is unique among transcription factor families. Using partially degenerate oligonucleotides from conserved regions of the ETS domain and the polymerase chain reaction, we isolated a new member of the v-ets family designated PE-1 from HL60 cells. PE-1 was expressed as an approximately 7.5-kb transcript in most cell lines tested. In the hairy cell leukemia line Eskol, there was an additional 1.8-kb transcript observed. PE-1 was the most common ETS domain gene found in CD34+HLA-DR- hematopoietic progenitors. PE-1 was localized to human chromosome 1q21-q23 using both in situ chromosomal hybridization and human-hamster hybrids. |
