| First Author | Aida Y | Year | 1994 |
| Journal | Biochem Biophys Res Commun | Volume | 204 |
| Issue | 1 | Pages | 195-202 |
| PubMed ID | 7945359 | Mgi Jnum | J:20961 |
| Mgi Id | MGI:69015 | Doi | 10.1006/bbrc.1994.2444 |
| Citation | Aida Y, et al. (1994) Cloning of cDNAs and the molecular evolution of a bovine MHC class II DRA gene. Biochem Biophys Res Commun 204(1):195-202 |
| abstractText | Two overlapping cDNA clones coding for bovine major histocompatibility complex (MHC) class II antigen DRA chain were isolated and characterized. The full-length cDNA clone, MR1, encoded a primary translated product of 253 amino acids, 24 of which were deduced to be a signal peptide and 229 which formed a mature polypeptide. The amino acid sequences deduced from this clone resembled those of class II A molecules from other species in both size and structure, but no potential consensus site of N-linked glycosylation comparable to those in the human, mouse, rat and swine proteins was found in the alpha 2 domain, as well as ovine and equine DRA molecules. Comparison of amino acid sequences encoded by class II A genes among several species and a dendrogram constructed from these data places the DRA gene and the DQA/DYA genes on two distinct branches of a phylogenetic tree, with bovine DRA and ovine DRA being most similar on the DRA branch. |
