| First Author | Hockenbery DM | Year | 1995 |
| Journal | Bioessays | Volume | 17 |
| Issue | 7 | Pages | 631-8 |
| PubMed ID | 7646485 | Mgi Jnum | J:26887 |
| Mgi Id | MGI:74314 | Doi | 10.1002/bies.950170709 |
| Citation | Hockenbery DM (1995) bcl-2, a novel regulator of cell death. Bioessays 17(7):631-8 |
| abstractText | The bcl-2 gene product, a 25 kDa membrane protein residing at mitochondrial, microsomal and nuclear membrane sites within many cell types, is a broad and potent inhibitor of cell death by apoptosis. A family of bcl-2-related genes with death-inhibiting or -promoting actvities has recently been described, indicating a potentially quite complex cell death regulatory network at the level of gene expression and protein-protein interactions. The function of bcl-2 may be to regulate a final common pathway in apoptosis. Current hypotheses suggest that oxidative stress, specific proteolytic activity or cell cycle control may be common elements in apoptosis through which bcl-2 exerts its survival function. Based on the extent to which elements of apoptotic pathways overlap with non-apoptotic cellular functions, the physiological role of bcl-2 may also extend to other cellular processes such as differentiation and proliferation. |
