| First Author | Shimizu T | Year | 2005 |
| Journal | J Dent Res | Volume | 84 |
| Issue | 4 | Pages | 315-9 |
| PubMed ID | 15790735 | Mgi Jnum | J:97903 |
| Mgi Id | MGI:3576637 | Doi | 10.1177/154405910508400404 |
| Citation | Shimizu T, et al. (2005) Localization of am3 using EL Congenic Mouse Strains. J Dent Res 84(4):315-9 |
| abstractText | EL/Sea mice have 100% incidence of the absence of third molars (M3). Our previous linkage analysis using EL/Sea and MSM/Msf mouse strains provides statistical evidence of a major locus for the absence of M3, designated am3, of EL/Sea at the middle region of chromosome 3. To obtain independent evidence for linkage and more precisely determine the location of the am3 locus, we generated EL/Sea congenic strains for am3 in which the restricted interval of chromosome 3 of EL/Sea was replaced by an MSM/Msf-derived homologue. EL/Sea congenic mice that were either heterozygous or homozygous for the MSM/Msf-derived interval exhibited a significant decrease in the incidence of the absence of third molars, confirming previous genome scan results. These results confine the am3 locus to an approximately 4.4-cM region, and demonstrate that other unmapped genes are also involved in the absence of M3 in EL/Sea mice. |
