| First Author | Zhang H | Year | 2016 |
| Journal | Prostate | Volume | 76 |
| Issue | 4 | Pages | 402-8 |
| PubMed ID | 26660523 | Mgi Jnum | J:286344 |
| Mgi Id | MGI:6403535 | Doi | 10.1002/pros.23131 |
| Citation | Zhang H, et al. (2016) Nkx3.1 controls the DNA repair response in the mouse prostate. Prostate 76(4):402-8 |
| abstractText | BACKGROUND: The human prostate tumor suppressor NKX3.1 mediates the DNA repair response and interacts with the androgen receptor to assure faithful completion of transcription thereby protecting against TMPRSS2-ERG gene fusion. To determine directly the effect of Nkx3.1 in vivo we studied the DNA repair response in prostates of mice with targeted deletion of Nkx3.1. METHODS: Using both drug-induced DNA damage and gamma-irradiation, we assayed expression of gamma-histone 2AX at time points up to 24 hr after induction of DNA damage. RESULTS: We demonstrated that expression of Nkx3.1 influenced both the timing and magnitude of the DNA damage response in the prostate. CONCLUSIONS: Nkx3.1 affects the DNA damage response in the murine prostate and is haploinsufficient for this phenotype. |
