| First Author | Bjur E | Year | 2013 |
| Journal | PLoS Genet | Volume | 9 |
| Issue | 5 | Pages | e1003494 |
| PubMed ID | 23658533 | Mgi Jnum | J:197132 |
| Mgi Id | MGI:5490919 | Doi | 10.1371/journal.pgen.1003494 |
| Citation | Bjur E, et al. (2013) Distinct Translational Control in CD4(+) T Cell Subsets. PLoS Genet 9(5):e1003494 |
| abstractText | Regulatory T cells expressing the transcription factor Foxp3 play indispensable roles for the induction and maintenance of immunological self-tolerance and immune homeostasis. Genome-wide mRNA expression studies have defined canonical signatures of T cell subsets. Changes in steady-state mRNA levels, however, often do not reflect those of corresponding proteins due to post-transcriptional mechanisms including mRNA translation. Here, we unveil a unique translational signature, contrasting CD4(+)Foxp3(+) regulatory T (TFoxp3+) and CD4(+)Foxp3(-) non-regulatory T (TFoxp3-) cells, which imprints subset-specific protein expression. We further show that translation of eukaryotic translation initiation factor 4E (eIF4E) is induced during T cell activation and, in turn, regulates translation of cell cycle related mRNAs and proliferation in both TFoxp3- and TFoxp3+ cells. Unexpectedly, eIF4E also affects Foxp3 expression and thereby lineage identity. Thus, mRNA-specific translational control directs both common and distinct cellular processes in CD4(+) T cell subsets. |
