| First Author | Bankoti R | Year | 2012 |
| Journal | J Immunol | Volume | 188 |
| Issue | 8 | Pages | 3961-71 |
| PubMed ID | 22412197 | Mgi Jnum | J:184071 |
| Mgi Id | MGI:5320225 | Doi | 10.4049/jimmunol.1102880 |
| Citation | Bankoti R, et al. (2012) Marginal zone B cells regulate antigen-specific T cell responses during infection. J Immunol 188(8):3961-71 |
| abstractText | Marginal zone B cells (MZB) participate in the early immune response to several pathogens. In this study, we show that in muMT mice infected with Leishmania donovani, CD8 T cells displayed a greater cytotoxic potential and generated more effector memory cells compared with infected wild type mice. The frequency of parasite-specific, IFN-gamma(+) CD4 T cells was also increased in muMT mice. B cells were able to capture parasites, which was associated with upregulation of surface IgM and MyD88-dependent IL-10 production. Moreover, MZB presented parasite Ags to CD4 T cells in vitro. Depletion of MZB also enhanced T cell responses and led to a decrease in the parasite burden but did not alter the generation of effector memory T cells. Thus, MZB appear to suppress protective T cell responses during the early stages of L. donovani infection. |
