| First Author | Hippen KL | Year | 2000 |
| Journal | J Exp Med | Volume | 191 |
| Issue | 5 | Pages | 883-90 |
| PubMed ID | 10704468 | Mgi Jnum | J:124695 |
| Mgi Id | MGI:3722240 | Doi | 10.1084/jem.191.5.883 |
| Citation | Hippen KL, et al. (2000) CD5 maintains tolerance in anergic B cells. J Exp Med 191(5):883-90 |
| abstractText | Clonal anergy of autoreactive B cells is a key mechanism regulating tolerance. Here, we show that anergic B cells express significant surface levels of CD5, a molecule normally found on T cells and a subset of B-1 cells. Breeding of the hen egg lysozyme (HEL) transgenic model for B cell anergy onto the CD5 null background resulted in a spontaneous loss of B cell tolerance in vivo. Evidence for this included elevated levels of anti-HEL immunoglobulin M (IgM) antibodies in the serum of CD5(-/-) mice transgenic for both an HEL-specific B cell receptor (BCR) and soluble lysozyme. 'Anergic' B cells lacking CD5 also showed enhanced proliferative responses in vitro and elevated intracellular Ca(2+) levels at rest and after IgM cross-linking. These data support the hypothesis that CD5 negatively regulates Ig receptor signaling in anergic B cells and functions to inhibit autoimmune B cell responses. |
