| Primary Identifier | IPR045269 | Type | Family |
| Short Name | Atg1-like |
| description | This entry represents a group of Serine/threonine-protein kinases, including Atg1 from yeasts, Unc-51 from C. elegans, Ulk1-3 from humans and ATG1a/b/c/t from Arabidopsis.Atg1 is required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway [].Ulk1-3 are involved in autophagy in response to starvation [, ]. Ulk1 and Ulk2 regulate filopodia extension and branching of sensory axons. They are important for axon growth, playing an essential role in neurite extension of cerebellar granule cells [, ]. Unc-51 is important for axonal elongation and axonal guidance []. It is required for either the maintenance of axons (membrane turnover) or for an unknown neuronal function. C elegans worms lacking Unc-51 exhibit various abnormalities in axonal elongation and axonal structures. Unc-51 could also help control cell size along with Bec-1, as mutations in their corresponding genes results in a reduction in small body size without affecting cell number []. Unc-51 is also a component of the Unc-51/Atg-13 complex that is probably recruited by lgg-1 to preautophagosomes and is required for autophagosome formation [].In plants, the ATG1/13 complex is both a regulator and a target of autophagy []. |
