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Publication : Rat stromelysin 3: cDNA cloning from healing skin wound, activation by furin and expression in rat tissues.

First Author  Okada A Year  1997
Journal  Gene Volume  185
Issue  2 Pages  187-93
PubMed ID  9055814 Mgi Jnum  J:38546
Mgi Id  MGI:85927 Doi  10.1016/s0378-1119(96)00615-4
Citation  Okada A, et al. (1997) Rat stromelysin 3: cDNA cloning from healing skin wound, activation by furin and expression in rat tissues. Gene 185(2):187-93
abstractText  From a rat skin wound healing cDNA library, a clone encoding stromelysin 3 (ST3) was isolated. The predicted rat ST3 has 491 amino acids, and shows 83, 95 and 58% homology with human, mouse and Xenopus ST3, respectively. COS-1 cells transfected with this rat ST3 cDNA produced the ST3 proform, which could be converted to the mature ST3 form by co-transfection with rat furin cDNA. In addition to healing skin, the rat ST3 gene was found to be strongly expressed in normal adult uterus and ovary, and at lower levels in chemically-induced mammary tumors.
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