| First Author | Chen XD | Year | 2004 |
| Journal | FASEB J | Volume | 18 |
| Issue | 9 | Pages | 948-58 |
| PubMed ID | 15173106 | Mgi Jnum | J:118115 |
| Mgi Id | MGI:3698624 | Doi | 10.1096/fj.03-0899com |
| Citation | Chen XD, et al. (2004) The small leucine-rich proteoglycan biglycan modulates BMP-4-induced osteoblast differentiation. FASEB J 18(9):948-58 |
| abstractText | Biglycan (bgn) is a small leucine-rich proteoglycan enriched in extracellular matrices of skeletal tissues. Bgn-deficient mice develop age-related osteopenia with a phenotype that resembles osteoporosis and premature arthritis. In the present study, we have examined the differentiation of bgn-deficient osteoblasts from neonatal murine calvariae and found that the absence of bgn caused less BMP-4 binding, which reduced the sensitivity of osteoblasts to BMP-4 stimulation. The loss of sensitivity resulted in a reduction of Cbfa1 expression, which ultimately led to a defect in the differentiation of osteoblasts. However, the response of bgn-deficient osteoblasts to BMP-4 was completely rescued by reintroduction of biglycan by viral transfection. We propose that biglycan modulates BMP-4-induced signaling to control osteoblast differentiation. |
