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Publication : HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1-->p12 and mouse chromosome 6C3-D1.

First Author  Puliti A Year  1999
Journal  Cytogenet Cell Genet Volume  84
Issue  1-2 Pages  115-7
PubMed ID  10343123 Mgi Jnum  J:55280
Mgi Id  MGI:1337573 Doi  10.1159/000015234
Citation  Puliti A, et al. (1999) HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1-->p12 and mouse chromosome 6C3-D1. Cytogenet Cell Genet 84(1-2):115-7
abstractText  HOX11L1 is a homeobox gene involved in peripheral nervous system development as confirmed by knockout mice exhibiting megacolon with enteric ganglia, a phenotype associated in human with Intestinal Neuronal Dysplasia (IND). Using FISH and radiation hybrids we have localized HOX11L1 to human chromosome 2p13.1 --> p12, in a 14-cR interval between WI-5987 (D2S2088) and GCT1B4 (D2S2497), and confirmed the synteny between mouse 6C3D1 and human 2p13.1 --> p12 chromosomes by mapping an EST cDNA clone corresponding to mouse HOX 11L1 (Tlx2).
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