| First Author | Jakkaraju S | Year | 2005 |
| Journal | Dev Cell | Volume | 9 |
| Issue | 1 | Pages | 39-49 |
| PubMed ID | 15992539 | Mgi Jnum | J:99401 |
| Mgi Id | MGI:3582105 | Doi | 10.1016/j.devcel.2005.04.015 |
| Citation | Jakkaraju S, et al. (2005) TIPs Are Tension-Responsive Proteins Involved in Myogenic versus Adipogenic Differentiation. Dev Cell 9(1):39-49 |
| abstractText | Stretch induces lung embryonic mesenchymal cells to follow a myogenic pathway. Using this system we identified a set of stretch-responsive factors, which we referred to as TIPs (tension-induced/inhibited proteins). TIPs displayed signature motifs characteristic of nuclear receptor coregulators and chromatin remodeling enzymes. A genomic BLAST search suggested that the three TIPs identified were isoforms originated by alternative splicing from a single gene. Functional studies revealed that TIP-1 and TIP-3 were involved in the cell's selection of the myogenic or the adipogenic pathway. TIP-1, induced by stretch, promoted myogenesis, while TIP-3, inhibited by stretch, stimulated adipogenesis. The selection involved TIP-mediated chromatin remodeling via a histone acetylation process and depended on TIP-1 and TIP-3 nuclear receptor binding boxes (NRBs). This study, therefore, suggests a new developmental mechanism linking the presence or absence of tension with divergent differentiation pathways. |
