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Publication : Differences in expression patterns between mouse connexin-30.2 (Cx30.2) and its putative human orthologue, connexin-31.9.

First Author  Nielsen PA Year  2003
Journal  FEBS Lett Volume  540
Issue  1-3 Pages  151-6
PubMed ID  12681499 Mgi Jnum  J:82732
Mgi Id  MGI:2654970 Doi  10.1016/s0014-5793(03)00252-7
Citation  Nielsen PA, et al. (2003) Differences in expression patterns between mouse connexin-30.2 (Cx30.2) and its putative human orthologue, connexin-31.9. FEBS Lett 540(1-3):151-6
abstractText  A novel gap junction forming protein, mouse connexin-30.2 (Cx30.2) contains 278 amino acid residues, and is 79% identical to human Cx31.9 (GJA11). Northern analysis showed that Cx30.2 is ubiquitously expressed, most prominently in testis. Polyclonal antibodies against Cx30.2 detected a 30 kDa protein in cells overexpressing Cx30.2, and in mouse testis. Immunofluorescence showed that Cx30.2 was expressed in vascular smooth muscle, but also in cell types where Cx31.9 was not detected. These data demonstrate that Cx30.2 is a bona fide gene, and suggest that it is the orthologue of Cx31.9, but that it may have additional roles compared with Cx31.9.
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