| First Author | Tang Y | Year | 2019 |
| Journal | Int J Biol Sci | Volume | 15 |
| Issue | 1 | Pages | 34-43 |
| PubMed ID | 30662345 | Mgi Jnum | J:309439 |
| Mgi Id | MGI:6755709 | Doi | 10.7150/ijbs.28879 |
| Citation | Tang Y, et al. (2019) E-cadherin is Required for the Homeostasis of Lgr5(+) Gastric Antral Stem Cells. Int J Biol Sci 15(1):34-43 |
| abstractText | Lgr5-expressing stem cells contribute to the epithelial turnover of the gastric antrum. However, the mechanism controlling the homeostasis of Lgr5(+) antral stem cells is not fully understood. Here, we demonstrate the key role of E-cadherin in the homeostasis of Lgr5(+) gastric antral stem cells. The deletion of E-cadherin in these cells results in their apoptosis, thereby leading to a marked decrease in their number. A reduced Lgr5(+) stem cell pool caused by the loss of E-cadherin impairs gastric antral epithelial homeostasis in vivo and organoid growth in vitro. Furthermore, p53 contributes to the apoptosis of Lgr5(+) stem cells following E-cadherin loss, while the simultaneous deletion of p53 rescues the phenotype in E-cadherin mutants. Our study reveals the critical pro-survival function of E-cadherin in Lgr5(+) gastric antral stem cells and the key role of the Lgr5(+) stem cell pool in the maintenance of gastric epithelial homeostasis. |
